Only one other case of desmoplastic ameloblastoma has been reported in the ramus region of mandible of the 90 cases that we have reviewed. Review of. Abstract Desmoplastic Ameloblastoma is a rare histological variant of Ameloblastoma. Approximately cases of desmoplastic Ameloblastoma have been. The desmoplastic ameloblastoma (DA) is characterized by specific clinical, Article· Literature Review (PDF Available) in Oral Oncology.

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This tumor is more commonly seen in the anterior region of jaws as a mixed radiopaque-radiolucent lesion resembling benign fibro-osseous lesions.

A Clinical Case Report. In view of the paucity of DA case series and the only limited understanding of its biologic behavior and prognosis, the proper treatment strategies for DA are not entirely defined so far. This article has been cited by. Concerning the biological behavior of DA, it is mentioned in the WHO classification of odontogenic tumors that DA, like unicystic ameloblastoma and peripheral ameloblastomas, possibly have a lower recurrence rate than other ameloblastomas.

Although no difference between genders has been reported 14 in the onset of this disease, people in the 4th and 5th decade are most commonly affected. The DA usually appears in the anterior and premolar regions as a mixed radiolucent and radiopaque lesion sometimes mimicking a benign fibro-osseous lesion. A histopathologic study of ameloblastomas with special reference to the desmoplastic variant.


Case Reports in Pathology

We presented a case of hybrid ameloblastoma and reviewed the 36 reported cases of hybrid ameloblastoma that have been reported in the English literature.

Race The incidence of DA among ameloblastomas ranges from 0.

Review of literature has revealed the tumour to most commonly occur in the 3rd to 5th decade of life with a high preponderance of Japanese males. Among the ameloblastomas, the desmoplastic variation is rare.

The patient is undergoing routine follow up. The lesion was treated via enucleation and curettage of the marginal bone and fenestration. A characteristic feature is an almost equal distribution in location between the maxilla and mandible.

Footnotes Source of Support: The latter study stated that the origin of hybrid lesions is unclear and therefore it remains unknown if DA develops from conventional ameloblastoma, conventional ameloblastoma develops from DA, or hybrid ameloblastoma is a kind of collision desmoplaetic. Columnar cells demonstrating reversed nuclear polarity are rarely conspicuous although some islands may show ameloblast-like cells peripherally.

Waldron andel-Mofty 1 14 cases. In addition, areas of cystic degeneration and squamous metaplasia were also seen Figure 5.

Desmoplastic ameloblastoma – A review.

Desmoplastic Ameloblastoma a Hybrid Variant: These expressions might contribute to the distinct characteristics of DA. Author information Copyright and License information Disclaimer. Journal of Craniofacial Surgery. Summary of data on 35 compiled cases of hybrid ameloblastoma.


The swelling was slow in growth and present since 4 months. Radiologically, there is not any agreement among DA reviews as to whether it demoplastic with a radiolucent or mixed radiolucent— radiopaque lesion. Management Treatment methods were mentioned in 83 out of cases.

Desmoplastic ameloblastoma with osteoplasia: Review of literature with a case report

Pathology of the desmoplastic ameloblastoma. Hence it can be suggested that if the desmoplasia is caused by tumor cell stimulation of stromal fibroblasts, then that stimuli could also affect another cell type, i.

An image of the oral cavity obtained during the initial examination showing a painless mass in the lower right premolar region. Whether the recurrence is due to the nature of the tumor or due to the incomplete surgery remains speculative. Various immunohistochemical studies have reported DA tumor cells as showing variable expression of S protein and desmin, high expression of caspase-3 and Fas, decreased expression of cytokeratin 19 and high expression of p A painless swelling or bony expansion are the most conspicuous clinical manifestation in most cases [ 2 — 5 ].

Case Reports in Pathology. Grade I mobility of 21 and 22 was also noticed.